Goblet cell adenocarcinoma of the appendix with ovarian metastasis and synchronous adenocarcinoma of the sigmoid colon: A case report

Abstract

Appendiceal goblet cell adenocarcinoma (GCA) is an amphicrine tumor composed of goblet-like, and variable numbers of endocrine and Paneth-like cells, typically arranged as tubules resembling intestinal crypts. As a rare cancer, the characteristics of and appropriate treatment strategy for GCA have not been fully elucidated. Here, we describe a case of an appendiceal GCA detected during sigmoidectomy for synchronous sigmoid colon adenocarcinoma and discuss whether appendiceal GCA coexisted incidentally. A 78-year-old woman was referred to our institution due to severe anemia. Colonoscopy and computed tomography revealed circumferential sigmoid colon cancer and a primary or metastasized ovarian tumor. We performed a laparoscopic sigmoidectomy and bilateral adnexectomy. The appendix appeared infiltrative and indurated, and appendectomy was performed. Immunohistochemistry revealed sigmoid colon adenocarcinoma and appendiceal GCA with ovarian metastasis. GCAs should be considered when ovarian tumors are detected with other abdominal malignancies.